Christian A. Kjellmo disputerer for ph.d.-graden i helsevitenskap 27. oktober

Kjellmo vil offentlig forsvare avhandlingen «Assessment of LDL and HDL Subfractions and Metrics of HDL Function in High-Risk Patients of Cardiovascular Disease: Evaluation of Four Different Interventions».​ 

Avhandlingen er tilgjengelig her

The doctoral thesis

Opptak av disputasen vil være tilgjengelig i et døgn (a recording of the disputation will be available for 24 hours).

De som ønsker å opponere ex auditorio kan sende e-post til leder av disputasen. 
Opponents’ ex auditorio should sign up to leader of defense by e-mail to: eirik.h.ofstad@uit.no​ 

Populærvitenskapelig sa​​mmendrag av avhandlingen

Atherosclerotic cardiovascular disease (ASCVD) is the leading global cause of death and disability. It occurs when low-density lipoprotein (LDL) particles enter artery walls, forming plaques that block blood flow that can cause heart attacks and strokes. High-density lipoproteins (HDL) are protective against ASCVD. Identifying high-risk individuals is challenging, and treatment often starts in advanced stages of disease. Advanced lipoprotein testing has been suggested to improve risk assessment and enable earlier and more high-intensity treatment with LDL-lowering therapies for high-risk patients. Our research used Lipoprint® to study LDL and HDL subgroups in high-risk patients included in four interventional trials aimed at reducing ASCVD risk. We found low baseline levels of high-risk LDL subfractions and no significant improvement with interventions. Some interventions impacted HDL subfractions, but HDL function was not significantly improved. In conclusion, Lipoprint® did not provide additional clinically relevant information.

​​​​Hovedveileder 

Førsteamanuensis Anders Wilhelm Hovland, Institutt for klinisk medisin, UiT - Norges Arktiske Universitet, Fakultet for sykepleie og helsevitenskap, Nord Universitet. 

Bive​iledere 

Professor Knut Tore Lappegård, Institutt for klinisk medisin, UiT- Norges Arktiske Universitet. 

Bedømmelseskomité

• Dosent Lennart Nilsson, Linkjøpings Universitet  - 1. opponent.
• Førsteamanuensis Vibeke Telle-Hansen, OsloMet - 2. opponent.
• Professor Eyvind Paulssen, Institutt for klinisk medisin, UiT- Norges Arktiske Universitet – leder av komité.
• Disputasleder: Førsteamanuensis Eirik Hugaas Ofstad, Institutt for klinisk medisin, UiT- Norges Arktiske Universitet.